1550 Engineering Drive, Rm 2152
Madison, WI 53706
BS 1997, Chemical Engineering, University of Michigan, Ann Arbor, MI
PhD 2001, Chemical Engineering, Rice University, Houston, TX
Postdoc 2001-2003, Chemical Engineering, University of Colorado, Boulder, CO
Kristyn Masters' lab's research focuses on the role of the tissue microenvironment in regulating cellular function and dysfunction. Specifically, her lab applies biomaterials and tissue engineering techniques to create tailored, controlled 3-D platforms which are used to mimic both healthy and diseased native environments. These engineered tissues may then be used to investigate phenomena such as cellular decision-making processes, how the microenvironment affects cellular sensitivity to drugs or other stimuli, or the sequence of events in the development of various pathologies. Masters' work generally focuses upon cardiovascular tissues, which includes the study of angiogenesis. Her work in angiogenesis has more recently led her to look at applications in the eye, as numerous diseases of the eye (e.g., age-related macular degeneration, diabetic retinopathy) are related to pathological angiogenesis. In order to better understand the microenvironmental factors that drive pathological angiogenesis in these diseases, as well as potentially identify novel targets for treatment, one of her labs' research goals is the development of a tissue-engineered model of the retina.