Huang, H., G. Jing, J. Wang, N. Sheibani, and S. Zhang. ATF4 Is a Novel Regulator of MCP-1 in Microvascular Endothelial Cells. J Inflamm (Lond), 2015, p. PubMed Text.
Abstract
Background: Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that recruits monocyte/macrophage to the site of tissue injury and plays a critical role in microvascular complications of diabetes. However, the mechanisms underlying the regulation of MCP-1 are not fully understood. The present study aims to explore the role of activating transcription factor 4 (ATF4), an ER stress-inducible transcription factor, in regulation of MCP-1 expression and production in brain and retinal microvascular endothelial cells.
Keywords: Activating transcription factor 4; Microvascular endothelial cells; Monocyte chemoattractant protein 1.