Evaluating a prototype transplantation device to deliver scaffolds into the rodent subretinal space

Abstract

Purpose

Synthetic scaffolds can promote the organized delivery of cells for stem cell based replacement therapies. Animal testing is often performed in rodents, however, subretinal scaffold transplantation into the small rodent eye is technically challenging. The purpose of this study was to evaluate a custom made transplantation device that can fold scaffolds into a small insertion tip designed to reduce surgically induced trauma.