Dow, C., and C. Harley. Evaluation of an Oral Telomerase Activator for Early Age-Related Macular Degeneration - a Pilot Study. Clin Ophthalmol, 2016, p. PubMed Text.
Abstract
Purpose: Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, provides a model for the use of TAs in age-related disease.
Keywords: drusen; macular degeneration; micro-perimetry; senescence; telomerase activation; telomere.