Madrigal, A., I. Lee, R. Xie, S. Min, J. Zhu, J. Jin, A. Ludwig, M. Phillips, S. Gong, Z. Ma, and D. Gamm. Incorporation of HPSC-Derived Photoreceptors and RPE Cells into Microfabricated, Honeycomb-Patterned Microscaffolds for Outer Retinal Reconstruction. Investigative Ophthalmology & Visual Science, 2023, p. Epub Full Text.
Abstract
Purpose
Blinding retinal diseases such as late-stage of age-related macular degeneration require the replacement of both retinal pigment epithelium (RPE) and photoreceptors (PRs). However, co-delivery of these cell types as an organized bilayer is technically challenging. To address this issue, we developed a 3D honeycomb (HC)-patterned, poly(glycerol sebacate) (PGS) micro-molded scaffold capable of organized reconstruction of the RPE-PR bilayer.