Falero-Perez, J., S. Gong, O. Mezu-Ndubuisi, J. Schoephoerster, N. Sheibani, Y. Wang, and I. Zaitoun. Intravitreal Delivery of VEGF-A165-Loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. Current Eye Research, 2019, p. Epub PubMed Text.
Abstract
Purpose: Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascularization with reduced levels of vascular endothelial growth factor (VEGF) causing vaso-obliteration (Phase I), followed by abnormal neovascularization from increased VEGF (Phase II). We hypothesized that intravitreal pro-angiogenic VEGF-A in microparticle form would promote earlier retinal revascularization in an oxygen-induced ischemic retinopathy (OIR) mouse model.
Keywords: Retinopathy of prematurity; microparticle; oxygen-induced retinopathy; retinal angiogenesis; vascular endothelial growth factor.