Sinha, D., G. Rathnasamy, K. Toops, M. Wilson, R. Valiauga, L. Tan, J. Eells, A. Lakkaraju, and D. Gamm. Modulation of Mitochondrial Respiration in HPSC-RPE. Investigative Ophthalmology & Visual Science, 2017, p. Epub Full Text.
Abstract
Purpose
Efficient mitochondrial activity is required to meet the energy demands of RPE, which is a highly metabolically active monolayer of cells possessing multiple critical roles in the outer retina. Given the interest in human pluripotent stem cell-derived RPE (hPSC-RPE) as a source for cell replacement therapies, it is important to investigate mitochondrial health and behavior in hPSC-RPE under relevant environmental conditions, which may in turn improve transplantation strategies.