Zhao, L., J. Li, Y. Fu, M. Zhang, B. Wang, J. Ouellette, P. Shahi, B. Pattnaik, J. Watters, W. Wong, and L. Guo. Photoreceptor Protection via Blockade of BET Epigenetic Readers in a Murine Model of Inherited Retinal Degeneration. J Neuroinflammation, 2017, p. PubMed Text.
Abstract
Background: The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activation. These epigenetic “readers” play crucial roles in pathogenic processes such as inflammation. The role of BETs in influencing the degenerative process in the retina is however unknown.
Keywords: Bromodomain and extraterminal domain (BET) proteins; Epigenetic readers; JQ1; Microglial activation; Retinal degeneration; rd10 mice.