Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

Aktas, Z., H. Rao, S. Slauson, B. Gabelt, I. Larsen, R. Sheridan, L. Herrnberger, E. Tamm, P. Kaufman, and C. Brandt. Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork. Invest Ophthalmol Vis Sci, 2018, p. PubMed Text.

Abstract

Purpose: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS).