Dharmarajan, S., C. Carrillo, Z. Qi, J. Wilson, A. Baucum II, C. Sorenson, N. Sheibani, and T. Belecky-Adams. Retinal Inflammation in Murine Models of Type 1 and Type 2 Diabetes With Diabetic Retinopathy. Diabetologia, 2023, pp. 2170-2185 Abstract
Aims/hypothesis
The loss of pericytes surrounding the retinal vasculature in early diabetic retinopathy underlies changes to the neurovascular unit that lead to more destructive forms of the disease. However, it is unclear which changes lead to loss of retinal pericytes. This study investigated the hypothesis that chronic increases in one or more inflammatory factors mitigate the signalling pathways needed for pericyte survival.