Retinal Thickness and Morphology Changes on OCT in Youth with Type 2 Diabetes: Findings from the TODAY Study

Mititelu, M., D. Uschner, L. Doherty, P. Bjornstad, A. Domalpally, K. Drews, R. Gubitosi-Klug, L. Levitsky, J. Pak, N. White, and B. Blodi. Retinal Thickness and Morphology Changes on OCT in Youth With Type 2 Diabetes: Findings from the TODAY Study. Ophthalmol Sci, 2022, p. Epub PubMed Text.

Abstract

Objective: To evaluate changes in retinal thickness and morphology using OCT in youth with type 2 diabetes (T2D) and to identify systemic biomarkers correlating with these changes.

Keywords: DR, diabetic retinopathy; EZ, ellipsoid zone; Glycemic control; HbA1c, glycated hemoglobin; ILM, internal limiting membrane; INL, inner nuclear layer; Macular morphology; NPDR, nonproliferative DR; OPL, outer plexiform layer; PVD, posterior vitreous detachment; Posterior vitreous detachment; RPE, retinal pigment epithelium; Retinal thickening; SD-OCT, spectral-domain OCT; T2D, type 2 diabetes; TD-OCT, time-domain OCT; TODAY, Treatment Options for Type 2 Diabetes in Adolescents and Youth; Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study.