Ludwig, A., J. Phillips, L. Jager, K. Nilles, S. Stuedemann, J. Lee, I. Lee, S. Gong, Z. Ma, and D. Gamm. Transplantation of Human Pluripotent Stem Cell-Derived Photoreceptors on a Biocompatible Scaffold in the S334ter Rat. Investigative Ophthalmology & Visual Science, 2019, p. Epub Full Text.
Abstract
Purpose
Disorganization of retinal grafts and reflux of donor cells during surgery can prevent optimal cell delivery in photoreceptor (PR) transplantation. For this study, we transplanted a novel biocompatible scaffold seeded with human pluripotent stem cell (hPSC)-derived PRs in the S334ter rat model of retinitis pigmentosa. To determine the impact of donor cell maturity on graft survival and cell differentiation in vivo, cells were transplanted at early- and mid-stages of differentiation.