Chan, K., K. Gibson, S. Gloe, M. Hoon, E. Jansen, J. Kiland, G. McLellan, B. Pattnaik, J. Roullet, G. Salomons, J. Ver Hoeve, K. Vogel, B. Wahlgren, D. Walters, B. Wetherbee, and J. Williams. Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. Investigative Ophthalmology & Visual Science, 2020, p. Epub PubMed Text.
Abstract
Purpose: Vigabatrin (VGB) is an effective antiepileptic that increases concentrations of inhibitory γ-aminobutyric acid (GABA) by inhibiting GABA transaminase. Reports of VGB-associated visual field loss limit its clinical usefulness, and retinal toxicity studies in laboratory animals have yielded conflicting results.