Wei-Hua Lee

Credentials: Assistant Scientist, Department of Medical Genetics

Email: weihua.lee@wisc.edu

Phone: (352) 871-3423

Address:
5350 Genetics-Biotechnology Center
425 Henry Mall
Madison, WI 53706

Education:

BS 2003, Biology, National Taiwan Normal University

MS 2006, Biological Sciences, University of Iowa, Iowa City, IA

PhD 2012, Medical Science (Neuroscience), University of Florida, Gainesville, FL

Research Interests:

Wei-Hua Lee, PhD is an assistant scientist of department of medical genetics at University of Wisconsin-Madison. Her research interest is to understand the mitochondrial function and energy metabolism in the retina/RPE and identify the metabolic basis for retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited forms of retinal degeneration. The goal is to use this knowledge to prevent or slow down retinal degeneration in
patients.

Her specific vision-related research projects include:
• Identifying novel genes that cause early retinal aging and age-related macular degeneration in mouse models
• Metabolic, cellular and molecular alterations during dysregulation of mitochondrial dynamics in retinal pigment epithelium (RPE) cells
• NAD+ precursors and knocking out PARP1 improve vision, retinal health, reduce inflammation, and enhance balance in aging mouse models
• Inflammation and neurodegeneration in mouse retina and CNS
• Quantitative trait locus (QTL) analysis in mouse models with RPE degeneration and an early sudden death phenotype

Publications:

Bhute VJ, Bao X, Dunn KK, Knutson KR, McCurry EC, Jin G, Lee WH, Lewis S, Ikeda A, Palecek SP. (2017). Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes. Theranostics. 7(7):2078-2091.

Lee WH, Higuchi H, Ikeda S, Macke E, Takimoto T, Pattnaik B, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta R, Thomson J, Mullins R, Takahashi J, Pinto L, Ikeda A. (2016). Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. eLife 5;e19264

Higuchi H, Macke E, Lee WH, Miller S, Xu J, Ikeda S, and Ikeda A. (2015). Genetic basis of age-dependent synaptic abnormalities in the retina. Mammalian Genome 26(0):21-32.

Lee WH, Kumar A, Rani A, Foster TC. (2014). Role of antioxidant enzymes in redox regulation of Nmethyl-D-aspartate receptor function and memory in middle-aged rats. Neurobiology of Aging. 35(6):1459-1468

Lee WH, Kumar A, Rani A, Herrera J, Xu J, Someya S, Foster TC. (2012). Influence of viral vectormediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging. Antioxidant & Redox Signaling. 15:16(4): 339-50

Kumar A, Rani A, Tchigranova O, Lee WH, Foster TC. (2012). Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology. Neurobiology of Aging. 33(4): 828.e1-17

Rangaraju S, Hankins D, Madorsky I, Madorsky E, Lee WH, Carter CS, Leeuwenburgh C, Notterpek L. (2009). Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell. 8, 178-191

Peng IF, Berke BA, Zhu Y, Lee WH, Chen W, Wu CF. (2007). Temperature- dependent developmental plasticity of Drosophila Neurons: Cell-autonomous roles of membrane excitability, Ca2+ influx, and cAMP signaling. The Journal of Neuroscience. 27 (46): 12611-12622