Coat Protein Complex II (COPII) is an enormously important protein that is responsible for transporting approximately one third of all proteins that function in mammalian cells. In a recently published paper in Nature Communication, the Audhya team describes how, using genome editing and live cell imaging, they were able to identify that a single protein called Sec23 is a central regulator of COPII. This significantly advances our understanding of COPII, and could eventually help researchers to develop new treatments for diseases like cancer, diabetes and those that cause immune dysfunction. Read the full story here.