Kayley Manuel
Position title: Graduate Student
Email: kmanuel@wisc.edu
Website: Neumann Lab
Address:
671 Med. Sci
1300 University Ave
Madison, WI 53706
Advisor: Donna Neumann, Phd
Keywords: HSV-1, epigenetics, chromatin loops, CTCF insulators, latency and reactivation
Research Summary
The Neumann lab studies Herpes Simplex Virus Type 1 (HSV-1), it is a significant human pathogen and is present in ~2/3 of the global population. HSV-1 can infect the cornea to establish a lifelong latent infection in sensory neurons that can undergo multiple reactivation events leading to recurrent infection in the eye. HSV-1 is a leading cause of blindness due to an infectious agent. Our lab is interested in understanding the molecular mechanism by which the virus enters latency and can undergo reactivation. We specifically study how the role of chromatin insulators (CTCF insulators) regulates these viral infection cycles.