Michael Landowski, PhD
Credentials: Postdoctoral Fellow, Department of Medical Genetics
5322 Genetics-Biotechnology Center
425 Henry Mall
Madison, WI 53706
BS 2009, Genetics, University of Wisconsin-Madison, Madison, WI
PhD 2018, Genetics and Genomics, Duke University, Durham, NC
As a postdoctoral trainee in the lab of Dr. Aki Ikeda, Dr. Landowski will investigate the molecular pathways disrupted by genetic mutations that accelerate the formation of age-dependent retinal pathologies in mice. His studies will focus on mice with a mutation in transmembrane protein 135 (Tmem135) that display age-dependent retinal pathologies such as RPE abnormalities, photoreceptor degeneration and visual loss. TMEM135 is a mitochondria-associated protein believed to regulate mitochondria dynamics, but the mechanism by which TMEM135 protects an eye from age-dependent pathologies is unknown. Working with Dr. Ikeda, he will use genetic techniques to identify and interrogate pathways perturbed by the TMEM135 deficiency in mice.