Anna Shen, PhD
Credentials: Department of Oncology
Position title: Research Scientist
Email: alshen@wisc.edu
Phone: (608) 262-1209
Address:
426 McArdle Cancer Research Building
1400 University Avenue
Madison, WI 53706
Education
BS 1975, Chemistry, Massachusetts Institute of Technology
MS 1977, Biochemistry, University of Pennsylvania
PhD 1980, Pharmacology, University of Wisconsin-Madison
PostDoc 1980-1983, Genetics, University of Wisconsin-Madison
Research Interests
Anna Shen is working to identify and characterize the mouse PPCD1 gene (initially termed “BigEye” mouse). The PPCD1 mouse exhibits a particular class of corneal abnormality affecting the corneal epithelium, with patterns remarkably similar to those observed in human corneal endothelial dystrophies—notably posterior polymorphous dystrophy (PPD). Secondary phenotypes observed in PPCD1 mice include corneal neovascularization, retinal ganglion cell loss, and photoreceptor loss, all significant causes of blindness in humans. Dr. Shen’s work focuses on providing a molecular explanation for the PPCD1 phenotypes with hopes of shedding light on human disease.
Publications
PubMed Listing of Publications