Credentials: Microbiology Doctoral Training Program, Dept. of Ophthalmology and Visual Sciences (School of Medicine and Public Health)
Position title: PhD Student
Advisor: Donna Neumann, PhD
Keywords: HSV-1, latency and reactivation, epigenetics, chromatin loop, CTCF insulators
BSc 2020, Microbiology, Indiana University Bloomington, Bloomington, IN
Ms. Ye is focused on studying Herpes Simplex Virus-1, which is the leading infectious cause of blindness worldwide. HSV-1 is known to establish lifelong latency in sensory neurons, where the virus can reactivate and have frequent recurrences. The 3-dimensional structure of viral chromatin silences lytic gene transcription during latency and poises the genome for reactivation. She is interested in studying how insulators direct and maintain chromatin loop formation in latency and thereby control lytic gene expression.